Cytokine levels in postmenopausal women depending on individual VDR, COL1A1, LRP5 gene polymorphisms
نویسندگان
چکیده
منابع مشابه
INFLAMMATORY BOWEL DISEASE Influence of IL-6, COL1A1, and VDR gene polymorphisms on bone mineral density in Crohn’s disease
Background: Osteoporosis is an important cause of morbidity in patients with Crohn’s disease. The pathogenesis of reduced bone mineral density (BMD) is multifactorial. A range of genetic factors have been implicated in other populations of patients with osteoporosis. Aim: To investigate the influence of interleukin 6 (IL-6), collagen type 1a1 (COL1A1), and vitamin D receptor gene (VDR) single n...
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Background: β-thalassemia as a hereditary disease is defined as defective synthesis of β-globin chains, resulting in erythropoiesis abnormalities and severe anemia. Different studies have shown that cytokines and cytokine gene polymorphisms play a major role in the pathogenesis of β-thalassemia. Single nucleotide polymorphisms (SNPs) within the promoter region or other regulatory sequences ...
متن کامل[Apa1 VDR polymorphism and osteoporosis risk in postmenopausal Mexican women].
AIM To analyze the association between Apa1 VDR polymorphism and osteoporosis in Mexican mestizo postmenopausal women. METHODS A cross-sectional study was conducted in 534 postmenopausal mestizo women from Mexico City to determine the association of the Apa1 Vitamin D Receptor gene polymorphism (rs7975232) with osteoporosis and osteoporosis plus fracture. Bone mineral density (BMD) was assess...
متن کاملCytokine gene polymorphisms in sarcoidosis.
BACKGROUND Sarcoidosis is a disease characterized by granuloma formation in many organs, but mostly in lung and lymph nodes. The immunopathogenic background of the disease is probably based on disregulation of immune response to different antigens. The imbalance of immune reactivity might be influenced by genetic background. In our study, we have investigated cytokine genetic polymorphisms in s...
متن کاملThe Vitamin D Receptor (VDR) Gene Polymorphisms Fok1 In Obese Pakistanis – a Preliminary Report
Objective: The role of vitamin D has soared to a pinnacle in recent years with functions affecting 229 human genes linked to cardiovascular, autoimmune, humoral, pulmonary and neurological diseases. Relationship between obesity and vitamin D has not as yet been fully established. The objective of the study was to determine the possible relationship between Vitamin D receptor (VDR) gene polymorp...
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ژورنال
عنوان ژورنال: Medical Herald of the South of Russia
سال: 2018
ISSN: 2219-8075
DOI: 10.21886/2219-8075-2018-9-2-67-74